Hiroyoshi Hattori, MD, PhD



Clinical Research Center
Chief, Laboratory of Advanced Therapy



Molecular biology in Cancer
Pediatric Hematology and Oncology


Contact Information

Clinical Research Center
Department of Hematology and Oncology Research
Laboratory of Advanced Therapy
National Hospital Organization Nagoya Medical Center
4-1-1 Sannomaru, Naka-ku, Nagoya
Aichi 460-0001, Japan
phone: +81-52-951-1111 ext. 6129
Fax: +81-52-963-5503


Area of Research

Therapeutic approach targeting a cancer specific genetic alteration



Dr. Hattori is interested in developing a cellular analytical platform to seek not only novel cancer specific targets but also understanding the context dependency influenced by a cancer specific mutation. His current projects include 1) to develop IKZF1 mutated human leukemia cells, with somatic gene targeting technique, which mimick IKZF1 mutated poor prognostic pediatric leukemia; 2) to investigate fusion genes in patients with bone and soft tissue sarcomas to approach a novel cancer therapy.


Selected Publications

  1. Sato K, et al. Current Biology, in press 2012.
  2. Hattori H, et al. Mol. Cancer Ther. 10: 670-678, 2011.
  3. Jeyasekharan AD, et al. Proc Natl Acad Sci U S A. 107: 21937-21942, 2010.
  4. Hattori H, et al. Leuk Res. 31:1633-164,. 2007.
  5. Hattori H, et al. Pediatr Hematol Oncol. 23:115-127, 2006
  6. Hattori H, et al. Br J Haematol. 115:472-475, 2001
  7. Hattori H, et al. Cancer. 88: 2372-2377, 2000



Hiroyoshi Hattori trained in hematology/oncology and general pediatrics at Shizuoka Children’s Hospital for 5 years after graduating from School of Medicine, Tottori University in 1993. He completed his PhD at Kyushu University in 2002, before receiving two research fellowships from the Foundation for Promotion of Cancer Research, at National Kyushu Cancer Center, and from the Japan Society for the Promotion of Science. He joined Hutchison/MRC Research Centre, University of Cambridge in UK as a research associate since 2005. He worked on developing an RNAi screen for DNA repair deficient cancers and the cellular DNA damage response under the supervision of Prof. Ashok Venkitaraman. In 2011, he joined the Department of Pediatrics, Nagoya Medical Center, Japan, before appointment to a chief of the laboratory of Advanced Therapy at Clinical Research Center from 2012.

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